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To the best of our knowledge, this is the first study to demonstrate that MEHP hinders CD8 + DC differentiation, at least in part through PPAR activation, in mice and in a Flt3L-supplemented culture system (see Figure 7 for schematic presentation)

however, at the same time temperature lowers the pKa of the acidic side chains in the C terminus thus facilitating the opposite effect of keeping fibrillation at bay