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Oral mucosal and epidermal melanocytes are histologically and ultrastructurally similar, but under physiological conditions, it seems that the former are intrinsically less metabolically active

Source: dermnetnz.org

Physiological oral mucosal melanin hyperpigmentation is very common in Blacks, in general is more frequent in darker-skinned than in lighter-skinned persons regardless of their race/ethnicity, and is most probably caused by genetically determined metabolic hyperactivity of oral melanocytes

2) Abnormalities in recognition memory and anxiety levels induced by a high-fat diet were reversed in response to treatment with Melanotan II