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Introductions Traumatic brain injury (TBI) is commonly found following traffic accidents in adults or perinatal asphyxia in newborns, which causes brain swelling with an increase in intracranial pressure and a subsequent decrease in cerebral perfusion leading to ischaemia ( Microtubules stability is a major determinant of axonal growth and neuronal polarization during axon formation ( Vitamin B 12 (Mecobalamin, MeCbl) is an important micronutrient that is required in numerous biological processes ( 12 deficiency results in methionine deficiency, leading to the dyes-synthesis of both phospholipids and myelin ( 12 is widely combined and used in clinical patients with nerve diseases

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The acetate salt form enhances stability and solubility