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In addition, the authors reported that the SUMO protease SENP5 negatively regulated mitochondrial fission by deSUMOylating SUMO1 from Drp1

Clin Cancer Res 15(10):3600-3609, 2009

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Previous research has also highlighted bioenergetic defects and disturbances in mitochondrial calcium homeostasis in NPCs carrying other mutations associated with LS (Ma et al., 2015