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The interconnections among these metabolic pathways create a complex regulatory network that supports AML cell survival and treatment resistance

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For example, CAN often presents with resting tachycardia and orthostatic hypotension, so nonpharmacologic strategies (such as adequate salt intake and physical activities and avoidance of medicine-related hypotension) and pharmacologic strategies (such as midodrine and droxidopa) should be considered to minimize postural symptoms rather than to restore normotension

This is why many people feel no difference when taking traditional pills