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Price: 21.19 USD
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243 TGF- signaling has a dual role in cancer, acting as a tumor suppressor in early stages and promoting invasion and metastasis in advanced malignancies

doi: 10.3389/fphys.2017.00718 40 ZhaoFWhitingSLambourneSAitkenRJSunYP

Foretinib is a class II inhibitor targeting c-MET, VEGFR2, Recepteurd Origine Nantais (RON), kinase insert domain receptor (KDR), and Fms related tyrosine kinase 1 (Flt-1) with potent inhibition of c-MET kinase activity (enzymatic IC50 1.16 nM) [100]