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HMGB1 serves as the main DAMP of ferroptosis and mediates the pathological effects of ferroptosis

It can be used both alone or with Selective Estrogen Receptor Modulator (SERM) therapy

First, to explore the existence of both individualized and group-level cortical SCAN regions, we placed a continuous line of seeds along the precentral gyrus and estimated their individual-specific or group-averaged RSFC, according to a previously described procedure 6

It is worth noting that bacterial composition and colonization is dynamic, not only diverse between individuals, but also in a single individual as trillions of microorganisms are constantly exposed to gut-environment changes (pH, temperature, etc.), diet-choices by the host, and other microbes