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The therapeutic potential of nanobodies

Iron has also been suspected as a culprit in the increased oxidative stress and lesions of dopaminergic neurons because of its potent reductive property (Jenner et al., 1992)

2012;7:e38901

In vitro studies suggest that this R152H mutation doesn't directly impact the enzyme's catalytic activity but rather interferes with its allosteric activation by cardiolipin [112]