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PMID: 15590179

doi: 10.1038/ncb3272 153 BottAJPengICFanYFaubertBZhaoLLiJet al

The biggest obstacle to the discovery of therapeutics for sepsis is its diverse etiology among patients (55), which have prompted researchers to study the molecular mechanism of sepsis progression based on systemic inflammatory responses

Furthermore, polymeric nanoparticles can be functionalized with ligands, antibodies, or targeting molecules to direct their cargo toward specific cells or tissues, thereby reducing off-target effects and improving vaccine efficacy [112]