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The level of infection-derived B-cell memory is predictive of the postvaccination response in immunized convalescent patients [229]

As a potent endogenous antioxidant, BR not only effectively scavenges superoxide and helps cells partially resist oxidative stress, but also possesses significant iron chelating ability, which effectively chelates Fe 2+ and Fe 3+ , alters the distribution of intracellular iron, and reduces the cellular uptake of iron, thus constituting an important part of the endogenous antioxidant defense system (Llido et al., 2023)

This bacterial species is Gram variable and spore-forming, hybridizes with the 16S rRNA-targeted oligonucleotide probe 5-GGG TAC TTA TTG CGT TTG CGA CGG CAC-3 54 , and has a 16S rRNA gene sequence that clusters within the monophyletic group in the Clostridiaceae that includes SFB from hosts such as the mouse, rat, turkey, chicken, and human

Development stage classification follows FDA guidance: pre-clinical = non-human efficacy