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These reactions are typically caused by localized immune responses or technique-related factors

One thing that immediately comes to mind is perhaps relying too heavily on one solution

CAR-T cells and combination therapies: whats next in the immunotherapy revolution

Navel V, Sapin V, Henrioux F, Blanchon L, Labb A, Chiambaretta F, Baudouin C, Dutheil F (2022) Oxidative and antioxidative stress markers in dry eye disease: a systematic review and meta-analysis