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People with the following should discuss risks carefully with a medical professional: Liver disease Kidney disease Pernicious anemia Known allergies to any ingredient in the formulation Pregnancy or breastfeeding (safety not well-studied avoid unless prescribed) Because ingredients differ between providers, always verify the formulation and follow prescribed dosing to minimize risk

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A 1 SD increase in B 12 (116 pmol/l) was associated with a 0.06 mmol/l lower FPG (95% CI 0.04, 0.08