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Description

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Invest 134, e176660

& Leib, D

In animal models, LR3 IGF-1 was approximately 2.5-fold more potent than native IGF-1 in promoting growth, with just 44 mcg/day of LR3 producing effects equivalent to 278 mcg/day of IGF-1 (Tomas et al., 1993)