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However, if feeling worse lasts more than a few days, this could be due to overmethylation, other gene variations such as an expressed CBS gene variation that may need to be supported before adding methylation support, or a sensitivity to the supplements, and the supplements should be discontinued

Toba, G

Hormones Insulin supports converting homocysteine (Hcy) to methionine, reducing cysteine and glutathione (GSH) production, and lowering GGT activity42

The catch is that production slows with age, and it's also affected by poor sleep, alcohol, pollution and chronic stress all fairly unavoidable if you live and work in a major Indian city