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The use of 3 H-Hinge to probe the interaction was based on the ability of 3 H-Hinge to bind specifically and with high affinity to HGF (Kawas et al., 2011)

A significant focus was on developing inhibitors of insulin-regulated aminopeptidase (IRAP), a protein identified as the AT4 receptor, with the goal of enhancing metabolic stability and BBB permeability

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When combined with mast cell-stabilizing peptides like KPV, stress management can produce synergistic improvements that neither approach achieves alone