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While theres no definite cutoff for when B12 starts to become unsafe, because people often ask, well somewhat arbitrarily say not to take more than 1,000 g per day over the long-term without guidance from a physician

Toll-like receptor 5 (TLR5), the PRR which recognizes flagellin on the epithelial surface, is also involved in the maintenance of gut microbiota homeostasis

We and others previously showed that rodent -cells do not synthesize significant L-DOPA or DA de novo, but produce ample quantities of DA in response to uptake of exogenous L-DOPA 6,7,9

I am over 70, male and in good health and take no meds other than an occasional NSID for muscle pains