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Among these, Aspergillus fumigatus derived gliotoxin is a well-characterized mitochondrial toxin that inhibits electron transport chain (ETC) complexes, induces excessive ROS generation, and triggers apoptosis in epithelial and immune cells (Warris and Ballou, 2019)

This creates the perfect environment for glutathione effectiveness

In human cervical cancer Hela cells, overexpression of GSTP1 was shown to not only inhibit the activation of JNK, as described above but also activation of p38 by suppression of the tumor necrosis factor receptor-related factor 2 (TRAF2), thereby playing a key regulatory role in TNF--induced MAPK signal transduction [11,64]

HSP60 also modulates the folding and function of TRiC client proteins, including STAT3, cyclins B and E, p53, and Von HippelLindau (VHL) protein