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Cystathionine -synthase CBS is well known for its role in the transsulfuration pathway, in which it catalyzes the -replacement of the hydroxyl group of serine with Hcy, forming the thioether cystathionine with release of water (H 2 O) (reaction 1)

Selenium and epigenetics DNA methylation DNMTs fall into two functionally distinct groups: DNMT1, which methylates DNA during replication to maintain methylation on newly synthesised DNA, and DNMT3a and DNMT3b, which are responsible for de novo DNA methylation during cell development and differentiation [57]

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While c-Myc DNA hypomethylation is observed in many different cancers, other examples of hypomethylated oncogenic loci are cancer-specific, such as the melanoma-associated antigens (MAGE) gene that is hypomethylated specifically in gastric cancer and colorectal cancer (Honda et al., 2004