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These factors contribute to abnormal microglial activation and the disruption of endothelial tight junctions, ultimately compromising the integrity of the neurovascular unit [33]

Alkylating/alkylating-like: Nitrogen mustards (Chlorambucil, Chlormethine, Cyclophosphamide, Ifosfamide, Melphalan, Bendamustine, Trofosfamide, Uramustine), Nitrosoureas (Carmustine, Fotemustine, Lomustine, Nimustine, Prednimustine, Ranimustine, Semustine, Streptozocin), Platinum (alkylating-like) (Carboplatin, Cisplatin, Nedaplatin, Oxaliplatin, Triplatin tetranitrate, Satraplatin), Alkyl sulfonates (Busulfan, Mannosulfan, Treosulfan), Hydrazines (Procarbazine), Triazenes (Dacarbazine, Temozolomide), Aziridines (Carboquone, ThioTEPA, Triaziquone, Triethylenemelamine)