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For instance, miRNAs associated with chemotherapy resistance, such as miR-23a-3p and miR-181c-5p, have been found to influence patient prognosis ( Traditional tissue biopsy remains a critical tool in HGSOC drug resistance research ( With the development of liquid biopsy technology, the indications for tissue biopsy are gradually being reconsidered

For example, female mice with IGF-1R knock-out were shown to be completely sterile, with no antral follicles and a 90% reduction in serum E2 levels (66)

13 Humic and Fulvic Acids: These natural compounds, derived from ancient plant matter, help bind heavy metals and environmental toxins, support gut barrier integrity, promote microbial balance, and enhance nutrient absorption

While transient aberrant changes associated with aluminum hydroxide salts are acknowledged, the direct link between microscopic muscle necrosis and the mechanisms underlying ME/CFS requires further investigation