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All plasmids were designed to integrate by double crossover recombination guided by 5 and 3 targeting regions that were amplified from P

Different chemical gradients being established throughout the biofilm community, in combination with limited diffusion and the metabolic activity of resident bacteria, leads to the emergence of distinct subpopulations that often cooperate metabolically but respond differently to the microenvironment depending on their location along the gradient (Penesyan et al., 2020)

Science 299:896899

PMID: 36157487 J Clin Invest THEMIS attenuates MASH by suppressing disease-associated hepatocyte induction and hepatocyte senescence in mice