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Isoquercetin has been shown to modulate the toll-like receptor 4 (TLR4) and NF-B, while the pharmacological activity of rutin revolves around inhibition of pro-inflammatory signals such as IL-6 and IL-1 signaling (Ma et al., 2018

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Ward PS, Patel J, Wise DR et al (2010) The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate