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Our previous findings revealed that under cholesteric conditions, the accumulated high levels of bile acids can promote the assembly of Apaf-1/caspase-4 pyroptosome, activating caspase-3-GSDME-executed pyroptosis and thereby cholestatic liver failure 16

[25] Vitamin E is a crucial antioxidant that is involved in numerous metabolic processes including, cell signaling and the regulation of gene expression

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5-amino-1MQ is a small, selective, membrane-permeable molecule that works to prevent the production of excess NNMT, targeting the source problem