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Ipser JC, Stein DJ, Hawkridge S, Hoppe L

Further evidence that Treg cells require ETC function comes from the observation that Treg cellspecific genetic loss of mitochondrial complex III function incurs fatal autoimmunity and increases antitumor immunity

Antigens activate the innate immune response through antigen-presenting cells and T cells, triggering an inflammatory cascade that also activates the adaptive immune system [44, 45]