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The next frontier in the ongoing campaign to reduce the global burden of asthma involves adopting network-modulating drugs, such as metformin, or adding pathway-specific inhibitors to existing therapies

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These findings consistently emphasize the importance of changes in the concentrations of various ions in the extracellular environment of neurons, and it is possible that targeting the concentrations of ions in the environment to permanently regulate the splicing of neurexins and thereby interfere with synaptic plasticity could be one of the mechanisms of sustained antidepressant effect

To counteract this vicious cycle, the heart is dependent on a robust mitochondrial quality-control system