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Nutr Cancer 50:206213 Juge N, Mithen RF, Traka M (2007) Molecular basis for chemoprevention by sulforaphane: a comprehensive review

Sensors 20 (4), 1072

By changing that positioning, we can partially restore FXN gene activity in diseased cells. While the findings are early and not a treatment, they point to genome organization itself as a contributor to disease and raise the exciting possibility that future therapies could work by changing how the DNA is organized inside the nucleus

This approach addresses challenges like rapid degradation and systemic toxicity by releasing cytokines only at the desired site (89, 90)