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FIGURE 1 Cocaine The World Drug Report estimates that worldwide, 18.8 million people used cocaine in 2014 (United Nations Office on Drugs and Crime, 2016)

73721 Magnetic resonance imaging (MRI) of lower extremity joint without contrast

doi: 10.3389/fimmu.2020.623691 10 ZhangWZouGLiBDuXSunZSunYet al

This enzyme requires the FAD coenzyme form of riboflavin for this reduction reaction, thus, emphasizing the role of riboflavin in the formation of reduced, active, glutathione ( Second, it has been shown that the oxidation of dihydroriboflavin, the reduced riboflavin, forming oxidized riboflavin can deactivate lipid peroxides, emphasizing the independent antioxidant property of riboflavin ( Third, riboflavin effects on antioxidant enzymes activities, including superoxide dismutase (SOD) ( Important to note, UV-B irradiation, the atmospherically predominant UV radiation, has been shown to reduce the neuroprotective effects of riboflavin both in vitro and in vivo