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Description

In the latter mice, the ADAM/Notch signaling pathway appeared upregulated in the skin, lung, fibroblasts, and splenocytes as in the skin biopsy samples taken from control patients affected by scleroderma [39]

Ethical statement The study used publicly available data

Cysteinylglycine (cys-gly) is produced from the hydrolysis of glutathione (glutamyl-cysteinyl-glycine), one of the most important endogenous free radical scavengers (Figures 1E, 3A)