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Goodwin RD, Kim JH, Weinberger AH, et al

53,73 The disulfide bond reduction and irreparable trimming of N -linked glycans generate degrons selectively modified with glycans such as Man 7 GlcNAc 2 , Man 6 GlcNAc 2 , or Man 5 GlcNAc 2 , which prevents substrate re-engagement with calnexin or calreticulin for nonproductive folding cycles

It is known that As(III) species are much more toxic than those of As(V) and that biological methylation can enhance or reduce the toxicity of the different forms