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The sandwich structured hydrogel further innovates the temporal release system, with the outer layer of SODm achieving rapid ROS scavenging (70% release within 24 h), while the inner layer, which is MMP-2 responsive, releases TGF-1 in a delayed manner, peaking at 48 h, which significantly enhances the expression of aggregated proteoglycans (Yang et al., 2024)

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In these smooth lesions, the presence of scale can be identified when the surface is gently scraped with a blade held perpendicular to the top of the lesion