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Urban J, Suchankova M, Ganovska M, Leksa V, Sandor F, Tedlova E

Direct comparison of ML226 treatment to lentiviral ABHD11 sgRNA depletion demonstrated that both pharmacological and genetic inhibition of ABHD11 reduced functional lipoylation on the E2 subunit of the OGDHc (dihydrolipoamide succinyltransferase (DLST), referred to as the OGDHc-E2) in preference to the E2 subunit of PDHc (dihydrolipoamide acetyltransferase (DLAT), referred to as the PDHc-E2

If gastrointestinal symptoms persist despite adequate hydration and supportive measures, your provider may consider dose reduction, temporary treatment interruption, or prescribing anti-emetic medications such as ondansetron or metoclopramide

This is consistent with Cartesian_ddG calculations