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This oxidative stress directly damages mitochondrial DNA and the delicate lipid membranes of the organelles

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95 In one randomized controlled trial involving 144 healthy participants with high non-restorative sleep scores, 120 mg of a standardized extract of ashwagandha root and leaf, called Shoden, daily for six weeks improved time to sleep onset, wakefulness after sleep onset, total sleep time, and sleep efficiency as measured by actigraphy

Given the expansion of the AR cistrome and the emergence of novel AR binding sites under ADT, similar to observations during carcinogenesis, it is tempting to speculate that other factors acting at or near AREs may be in play in CRPC