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Supplementary information Supplementary Table 1 (download XLSX Antibodies for immunoblotting Supplementary Table 2 (download XLSX Primers for qPCR Supplementary Table 3 (download XLSX List of quantified proteins with abundance ratio from LX-2 cells Supplementary Table 4 (download XLSX Quantification for -SMA and APOL2 immunostaining in human liver tissues Supplementary Table 5 (download XLSX List of proteins that interact with APOL2 in LX-2 cells Supplementary Table 6 (download XLSX RNA-seq data in LX-2 cells treated with DP Supplementary Table 7 (download XLSX Statistical source data for immunoblot quantitation Raw figures for IHC or H&E photos Source data Unprocessed western blots

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