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M., Galivan, J., Streckfuss, A

In contrast, patients initially treated with a placebo received no further treatment

The process of aging has been shown to diminish the efficacy of NRF2 activation, thereby complicating treatment outcomes for elderly patients

Indeed, pharmacological activation of NRF2 has been shown to reduce PC levels in the liver of a diet-induced nonalcoholic steatohepatitis rat model, in mouse maxillary nerves, and to lower 4-HNE levels in mouse islets (224226)