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In this way, the visceral nociceptive signals return to the dorsal horn of the spinal cord (e.g., at L1 or L2 level) and terminate on second-order neurons that send signals reaching the brain, where the pain is processed

It comprises 15 amino acids and has been described in the scientific literature as exhibiting notable stability under physiological conditions, particularly when compared with many endogenous peptide fragments, which has contributed to its use in experimental and preclinical research models

Several peptides in this category, including MOTS-c, have shown benefits for glucose metabolism and insulin sensitivity