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Transcellular pathway Lipids and lipophilic substances cross the intestinal barrier via diffusion along the apical plasma membrane of enterocytes into the circulation by the transcellular pathway

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Similarly, sibutramine (Meridia), a serotonin and dopamine reuptake inhibitor that works by inducing satiety and increasing energy expenditure 8 , was approved in 1997 against a background of divided opinion on its safety profile because, while effective for weight-loss, it tended to increase blood pressure and pulse rate 6