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In DSS and TNBS induced colitis models, orally administered KPV has consistently reduced disease activity scores, lowered inflammatory cytokine levels, decreased mucosal damage, and helped restore gut barrier function

In terms of sleep architecture, moderate doses of alcohol facilitate "rebounds" in rapid eye movement (REM) following suppression in REM and stage 1 sleep in the first half of an 8-hour sleep episode, REM and stage 1 sleep increase well beyond baseline in the second half

This is caused by increased metabolism in areas of the brain associated with movement, such as the nigrostriatal pathway

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