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Common signs of B12 deficiency include: Persistent fatigue that doesnt improve with rest Difficulty concentrating or brain fog Mood changes, including low mood or irritability Tingling or numbness in the hands and feet Weakness or shortness of breath with normal activity Pale skin or a smooth, swollen tongue B12 deficiency can develop silently for months before symptoms become noticeable, which is why its frequently missed

NAD+ is also a signaling molecule that tells DNA to increase transcription and translation to produce more proteins than the cells need to produce energy

Mitochondria and mood: mitochondrial dysfunction as a key player in the manifestation of depression