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The increase in lactate that we detected points towards a defect in oxidative energy metabolism, but this conclusion must be treated cautiously given the difficulty of measuring lactate in the presence of the much larger and broader macromolecule (MM) resonance at ~1.35 ppm, with the lactate signal being a small shoulder on that peak (Fig

Yan and Ajuwon (2017) discovered that stimulation with LPS results in a reduction in the levels of phosphorylated Akt and total Akt, subsequently leading to a decrease in the abundance of phosphorylated 4E-BP1