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Clinically, anxiety disorders encompass disorders such as generalized anxiety disorder (GAD), panic disorder, specific phobias, and social anxiety disorder (SAD), all marked by fear responses, behavioral avoidance, and heightened nervous arousal in perceived threatening situations (Wu et al., 2025)

Acta Endocrinol (Buchar) (2019) 15:2214

In addition, the interaction between tumor metabolism and the acidic microenvironment is bidirectional, as lower pH inhibits enzymes involved in glycolysis (such as phosphofructokinase-1) and may inhibit tumor cell proliferation and survival (112)