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This encapsulation technology works to protect the entrapped glutathione molecule in the core of liposomes from lysis by stomach or liver enzymes so that glutathione can more easily reach the cells that need it most and remain intact

Abbreviations % (v/v): Percent (volume per volume) C: Degree Celsius m: Micrometer a.m.: Ante meridiem CO 2 : Carbon dioxide Cyp11a1 : Cytochrome P450 family 11 subfamily A member 1 Cyp17a1 : Cytochrome P450 family 17 subfamily A member 1 Cyp19a1 :: Cytochrome P450 family 19 subfamily A member 1 ELISA: Enzyme-linked immunosorbent assay GH: Growth hormone GIPP: Gonadotropin-independent precocious puberty GnRH: Gonadotropin-releasing hormone Gnrh1 : Gonadotropin Releasing Hormone 1 HPG axis: Hypothalamus-pituitary-gonad axis hr.: Hour HSD17b: 17-hydroxysteroid dehydrogenase Hsd17b3 : Hydroxysteroid 17 dehydrogenase 3 Hsd3b: 3-hydroxysteroid dehydrogenase Hsd3b1 : Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Igf1: Insulin-like growth factor-1 IgG: Immunoglobulin G IU: International units kg: Kilogram Kiss1 : KiSS-1 Metastasis Suppressor L: Liter LCs: Leydig cells LH: Luteinizing hormone Lhb: Luteinizing hormone beta polypeptide Lhcgr : Luteinizing hormone/choriogonadotropin receptor mL: Milliliter mRNA: Messenger RNA PBS: Phosphate buffered saline PCR: Polymerase chain reaction PFA: Paraformaldehyde PLC: Progenitor Leydig cell PND: Postnatal day Prm : Protamine rhGH: Recombinant human growth hormone RNA: Ribonucleic acid Rpl7 : Ribosomal protein L7 rpm: Revolutions per minute RPMI: Roswell Park Memorial Institute medium RT-qPCR: Real-time reverse transcription-polymerase chain reaction Sf1 : Steroidogenic factor 1 Star : Steroidogenic acute regulatory protein T: Testosterone Tnp1 : Transition protein 1 Tnp2 : Transition protein 2 g: Microgram References Navarro VM, Fernandez-Fernandez R, Castellano JM, et al

Abnormal neutrophil recruitment in CF airways increases oxidative stress, causing redox imbalance and elastase/IL-8 release

Arnold, E