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Current preclinical and clinical data that supports the effectiveness of polyphenols in reducing the advancement of diseases, boosting cognitive abilities, and promoting overall brain health ( 2 Polyphenols pharmacological function to protect neuroinflammation and neurodegenerative diseases Neuroinflammation is a pathological process that involves the activation of glial cells and the subsequent production of pro-inflammatory cytokines, resulting in neuronal damage and impaired functionality (Figure 2) (Table 1 is a representation of the pharmacological function of polyphenols under different neurodegenerative diseases

McKusick V, Phillips JI, Hamosh A, Tiller G, O'Neill M

Then, centrifuge the homogenates for 5 minutes at 5000 g

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