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In patients with Parkinsons disease on levodopa monotherapy, vitamin B supplementation can increase peripheral levodopa metabolism and thus reduce the amount of levodopa reaching the central nervous system, worsening symptom control

These studies in anesthetized rabbits were undertaken to explore the possible mechanisms underlying the hemodynamic effects of hydroxocobalamin by investigating 1) possible hemodynamic effects of cyanocobalamin, which is formed on a molar-to-molar basis when hydroxocobalamin binds cyanide, and 2) the interference of hydroxocobalamin with the endothelial nitric oxide system

Distinct regulation of adiponutrin/PNPLA3 gene expression by the transcription factors ChREBP and SREBP1c in mouse and human hepatocytes

[DOI] [PubMed] [Google Scholar] 7.Nicholls DG, Locke RM