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UA supplementation was reported to induce the expression of the pathway [38,46]

(2) Selectively inhibits voltage-dependent Na + channels, which reduces or stops the release of neurotransmitters and vasoactive peptides, inhibits action potential propagation, and lessens focal discharges (DeLorenzo et al., 2000)

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Researchers believe that umami flavor may actually affect the brain in a way that helps decrease the risk for obesity, stimulate the metabolism, alter taste perception of bitter foods, boost satiety and fullness, and hold off hunger and cravings between meals