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doi:10.1016/j.phymed.2021.153654 Zhang SW, Zhou J, Gober HJ, Leung WT, Wang L

Concurrently, altered glucose metabolism in the orbitofrontal cortex and limbic regions reflects energy deficits and mitochondrial dysfunction, contributing to the severity of psychiatric symptoms, such as paranoia, agitation, and mood disturbances ( MRI studies have further identified gray matter atrophy in the prefrontal cortex, medial cingulate gyrus, and hippocampus, regions that are critically involved in memory, decision-making, and emotional regulation (Thompson et al., 2004)

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For example, as one of the significantly expressed miRNAs, miR-30e-5p was involved in the prevention of tumor growth and angiogenesis in gallbladder cancer via the PI3K/Akt pathway (Wang et al., 2020