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Annals of Nutrition & Metabolism, 60 , 293297

PTMs, especially phosphorylation of -syn, affect its iron-binding affinity, which may in turn influence the expression level of -syn protein and the conformation of -syn aggregates, forming a viscous cycle for Iron dysregulation impairs -syn clearance The clearance of intracellular -syn relies mainly on the selective autophagy and proteasome degradation [38]