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Due to the modifications to 425.512(a)(2)(iii) above, we are also finalizing to add a new paragraph (iv) at 425.512(a)(2) to establish that, for performance years 2027 and subsequent performance years, an ACO in the first performance year of the ACO's first agreement period under the Shared Savings Program will meet the quality performance standard if the ACO reports the APP Plus quality measure set and meets the data completeness requirement on all eCQMs/Medicare CQMs, and the CAHPS for MIPS survey (except as specified in 414.1380(b)(1)(vii)(B)), and receives a MIPS Quality performance category score for the applicable performance year

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The metabolic dysfunctions of these patients, such as obesity and insulin resistance, were almost entirely normalized, further validating the role of NMN in improving energy metabolism (Aflatounian et al., 2022)