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Results: Transient increases 3 to 31-fold from baseline in immune biomarkers associated with immune activation (sCD40, sCD28, sCD80, sCD86), Th1 cell-mediated response (IL-6, IL-12 p40, IL-12 p70, IL-7, IL-10), inflammation regulation (GROa, PDGF-AA, PDGF-AB, VEGF), and immune checkpoint proteins (PD-1, PD-L1, CTLA-4, LAG-3, BTLA) were observed during IDR lead-in, with peaks occurring during the plateau of HBsAg reduction in assessed subjects to date

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