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The resulting clean reads were assembled into unigenes using Trinity software (v2.13.2) after Q20, Q30, GC-content and sequence duplication level of the clean reads were calculated

Many preclinical studies conclusively shown that berberine plays a therapeutic role in many central nervous system disorders such as Alzheimer s disease, cerebral ischemia, depression, schizophrenia, epilepsy, and anxiety (Fan et al., 2017

Abstract Myalgic encephalitis/chronic fatigue syndrome (ME/CFS) is a common debilitating medical condition, whose main symptoms - fatigue, post-exertional malaise and cognitive dysfunction are also present in many cases of long COVID

The tissue microarrays (TMAs) were constructed as described previously ( H -score, a combination of the proportion of positive cells and the staining intensity, was applied to assess the results of IHC