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Resistance may also emerge through noncell-autonomous mechanisms, in which stromal elements such as CAFs sustain tumor metabolism through the Reverse Warburg Effect [325]

doi: 10.1002/prca.202300048

Furthermore, increased copper levels can increase reactive oxygen species (ROS) production and activate the NF-B signalling pathway, exacerbating inflammatory changes within the vascular wall and promoting atherosclerosis (25)